NEW STEP BY STEP MAP FOR PKRRATING

The activated enzyme then phosphorylates its main substrate, the translational initiation variable eIF2α. The resulting translational arrest blocks viral replication. PKR belongs to the conserved loved ones of four protein kinases (PKR, PERK, GCN2, HRI) that all phosphorylate eIF2α in response to various stimuli12, triggering the built-in anxiety